TMEM9 plays a significant role in TNF-induced IL-6 and IL-1 secretion in LX-2 cells, and its overexpression may increase the expression of the canonical Wnt/&bgr;-catenin signaling pathway.
Wei, W., Jiang, F., Liu, X., & Su, Q. (2018). TMEM9 mediates IL‐6 and IL‐1&bgr; secretion and is modulated by the Wnt pathway. International Immunopharmacology, 63, 253–260. https://doi.org/10.1016/j.intimp.2018.07.036.

• Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]
  

TMEM9 (Transmembrane Protein 9) is a Protein Coding gene. Diseases associated with TMEM9 include Snail Allergy. An important paralog of this gene is TMEM9B.